Multi-Organ-Chip platforms developed by German company TissUse GmbH consist of miniature structures that allow simulating the relationships between human organs with a physiological aspect.
Using these platforms, on a human-like model, we can directly predict for example, the metabolism and effects of test molecules and reduce or even replace testing on animal models. They make it possible to speed up the development process of pharmaceutical, chemical and cosmetic products, and allow developments in the field of personalized medicine.
- Microfluidic chip format of a standard microscopic slide
- Compatible with life tissue imaging
- On-chip micro-pump and natural tissue to fluid ratio
- Dynamic circulation with vascular perfusion
- Variable physiological shear stresses applicable
- Designed to work with existing lab equipment
- Rapid prototyping of any relevant chip design
The organ models are connected by microfluidic channels. An on-chip pump enables a near lifelike nutrient and oxygen supply to the cells. This allows for detailed studies of distribution and metabolization of various substances like drugs, cosmetics, chemicals, and food additives enabling the prediction of substance effects.
The HUMIMIC Chip3 is designed for the simultaneous cultivation of up to three organ models in a common microfluidic circuit. It gives you additional flexibility when selection your cell cultures due to its tailored design approach featuring organ compartments of varying size.
The HUMIMIC Chip 4 enables easy integration of up to four different organ models in one system. It supports relevant PK/PD modeling for quantitative in vitro to in vivo extrapolation and determination of ADME profiles (absorption, distribution, metabolism and excretion).